Did you know?

The phase solubility studies were performed according to the method described by Higuchi and. Connors [24]. Different concentrations of β-CD and HPβ-CD were ...Phase solubility techniques. T. Higuchi, A. Connors. Published 1965. Chemistry. No Paper Link Available. Save to Library. Create Alert. Cite. 2,644 Citations. Citation Type. More Filters. Environmentally friendly stability-indicating HPLC method for the …The phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double …... Higuchi-Connors phase solubility method. この論文は、ヒグチコンノル相溶解法 ... techniques including Fourier Transform Infrared Spectroscopy (FTIR) and ...The effects of βCD and MβCD on the solubility of SMT were studied as follows: an excess of SMT was added to aqueous buffered solutions of pH 2.0, pH 8.0, or water containing different amounts of βCD (0–13.2 mM) or MβCD (0–105 mM for water and 0–84 mM for pH 2.0 and 8.0). The resulting suspensions were sonicated in an ultrasonic …Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Oct 15, 2013 · Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ... The regression analysis (R 2 value 0.9434) of phase solubility data demonstrated A L type curves (Fig. 1 (a)) indicating 1:1 complexation between NCL and HP-β-CD as per Higuchi Connors classification (Higuchi & Connors, 1965). The apparent stability constant of the resultant niclosamide and HP-β-CD complex was found to be 747 M −1.Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ...The aqueous solubility of 1 linearly increased as a function of HP-β -CD concentration and showed features of an A -CD concentration and showed features of an AL type diagram. Thermodynamic parameters were obtained by using the temperature dependence of the stability constant at temperatures of between 25 and 37 type diagram.Phase solubility studies. The impact of the presence of BCD on the aqueous solubility of propolis extract was measured at different temperatures. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Saturated solution of BCD (15 mM) was prepared, heated at 50 °C and shaken until complete ...Guest–host interaction of astemizole (Astm) with cyclodextrins (CDs) has been investigated using phase solubility diagrams (PSD), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), proton nuclear magnetic resonance (1H-NMR) and molecular mechanical modeling (MM+). Estimates of the complex formation …Phase solubility studies were performed by the method previously reported by Higuchi and Connors . Briefly, excess amounts of darifenacin were added to 20 mL of aqueous solutions containing various concentrations of Hp βCD ... T. Higuchi and K. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and …The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ... Mar 10, 2023 · Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ). Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ...May 11, 2018 · Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives. Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on …In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...

Phase solubility profiles by Higuchi and Connors [45] Source publication. Mini Review on Synthesis and Characterization Methods for Ternary Inclusion Complexes of Cyclodextrins with Drugs....The phase solubility study was performed in water as per the reported method by Higuchi and Connors . An excess amount of resveratrol was added to a solution containing an increasing concentration of nanosponges. ... Higuchi, T., Connors, K.A.: Phase solubility techniques. In: Advances Analytical Chemistry and Instrumentation, …A phase-solubility study, where the drug (i.e. the substrate) solubility in moles/liter is plotted against the molar CD (i.e. the ligand) concentration, is one of the most common methods applied. Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles ( Higuchi and Connors, 1965 ).Phase solubility test Phase solubility studies were performed according to the methods described by Higuchi and Connors ( Higuchi & Connors, 1965 ). Excess amounts of quinestrol was suspended in a 0.1 mol/L phosphate buffer solution (pH 7.0) containing increasing amounts of DM-β-CD (from 0 mM to 10.00 mM).According to the classification method of Higuchi and Connors (Chen et al., Citation 2007; Higuchi & Connors, Citation 1965), ... Phase-solubility techniques. Adv Chem Instrum 4:117–212 [Google Scholar] Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet.

Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...Phase solubility of FA/HP-β-CD complex. Phase solubility studies were carried out according the method described by Higuchi and Connors’s methods (1965). Excess amounts of FA were added to 10 ml of water solution of HP-β-CDs at different concentrations ranging from 0 to 8.5 mM.Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...…

Reader Q&A - also see RECOMMENDED ARTICLES & FAQs. Phase-solubility measurements. Phase-solubility measurements were car. Possible cause: The phase solubility diagrams of DMY with α-CD, β-CD, γ-CD, HP-β-CD, and DM-β.